Hepatitis C virus appears not to be transmitted efficiently through occupational exposures to blood. One study determined transmission occurred from hollow-bore needles but not other sharps. Although these studies have not documented seroconversion associated with mucous membrane or non-intact skin exposure, at least two cases of HCV transmission from a blood splash to the conjunctiva and one case of simultaneous transmission of HCV and HIV after non-intact skin exposure have been reported.

No studies of transmission from HCV-infected DHCP to patients have been reported, and the risk for such transmission appears limited. Multiple reports have been published describing transmission from HCV-infected surgeons, which apparently occurred during performance of invasive procedures; the overall risk for infection averaged 0.17%.